Clinical highlights in this Issue

Alphs and colleagues used a mechanistic computer model to identify optimal ways to switch from oral antipsychotics to paliperidone palmitate monthly injections (PP1M) in schizophrenia. They observed that starting PP1M one day after the last oral dose or 4 weeks after a last long acting injectable medication was more optimal than a delayed beginning of PP1M after 1week with either a 1- or 2-week overlap with oral paliperidone. Clinicians need to evaluate how optimum efficacy can be rapidly achieved while avoiding potential loss of efficacy and safety concerns.

Source: Schizophrenia Research - June 23, 2018 Category: Psychiatry Authors: John Torous, Matcheri S. Keshavan Source Type: research