Procaine Induces Hyperactivated Motility in Stallion Spermatozoa by Inhibiting Sodium Influx

McPartlin et al. (Biology of Reproduction 2009; 81: 199 –206) reported promising fertilization results (61%) after co-incubating equine oocytes with spermatozoa treated with procaine to induce hyperactivated motility. We subsequently demonstrated that procaine directly affects equine oocytes, inducing sperm-independent cytokinesis; cleaved oocytes arre sted at 8-16 cells and daughter cells either lacked nuclei or contained condensed DNA fragments rather than normal nuclei (Leemans et al. 2015; Biology of Reproduction; 93: 23).

Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: B. Leemans, B.M. Gadella, T.A.E. Stout, A. Van Soom Source Type: research