Potential Roles for Inflammation and ‘Necroptosis’ in Age-Related Testicular Degeneration

We previously provided broad overviews of the transcriptomes of both normal and aged, degenerate equine testes (Woodward et. al, J Eq Vet Sci. 2016; 43:S66). Here, we compare these transcriptomes, as well as the transcriptomes from isolated Sertoli cells, and identify patterns of differential gene expression that provide insights into the pathophysiology of age-related testicular degeneration (TD) in the stallion. The hypothesis is that molecular pathways that are differentially regulated in degenerate testicular tissue compared to aged-matched, normal testicular tissue will reflect the underlying pathophysiology of TD.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research