Reactive Oxygen Species May Be Involved in the Signaling of Equine Sperm Chemotaxis

To find out the way to the oocyte, spermatozoa may be oriented by chemical cues (e.g., progesterone), transport mechanism called chemotaxis (Eisenbach et al. Reviews Molecular Cell Biology; 2006. 4:276-285). Only capacitated spermatozoa can orient their movement by chemotaxis, where part of the signaling (at least in humans) is mediated by the AC-cAMP-PKA pathway (Teves et al. PLoS ONE; 2009. 12: e8211) and oxidative state (Sanchez et al. Fertility and Sterility; 2010. 1:150-153). The aim of this work was to verify whether reactive oxidative species (ROS) are also involved in the chemotaxis signaling and by which mechanism.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research