Rosiglitazone Phosphorylates Akt, Reduces Caspase 3 Activity and Enhances Mitochondrial Function in frozen Thawed Stallion Spermatozoa

Spermatozoa surviving freezing - thawing, experience changes that represent an acceleration of the default apoptotic dead pathway that the spermatozoa experience after ejaculation[1]. One key protein related to survival is the Akt, provided that this kinase is phosphorylated (p-Akt), spermatozoa remain viable, but upon dephosphorylation of Akt pro-caspase 3 is cleaved and spermatozoa rapidly lose motility[2]. Cryopreserved semen show impaired mitochondrial function due to oxidative stress and the osmotic damage occurring at thawing[3].

Source: Journal of Equine Veterinary Science - June 23, 2018 Category: Veterinary Research Authors: M. Ortiz- Rodriguez, C. Ortega Ferrusola, M.C. Gil, F.J. Pe ña Source Type: research