Annexin A1, a Phospholipase A2 Inhibitor, Is Induced by Intrauterine Plastic Spheres

Intrauterine devices (IUDs) have been reported to induce prolonged luteal phases in mares. The mechanism is not known, although endometrial inflammation and mechanotransduction have been hypothesized. The aim of this study was to clarify mechanisms by which IUDs may prevent luteolysis. For that purpose, protein content of intrauterine fluid was analysed using two-dimensional difference gel electrophoresis (2D-DIGE). Twenty-seven reproductively normal mares aged 4-17 years were divided into two groups, the inseminated (AI) (n=12) and the intrauterine device (IUD) groups (n=15).
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research