A Closer Look at the Equine Feto-maternal Interface via High-throughput Sequencing

Despite the importance of the placental unit in pregnancy, to date, there has yet to be a large-scale study characterizing RNA expression in either chorioallantois or endometrium through gestation in any species. This type of dataset would be invaluable in furthering the understanding of the physiology of pregnancy in all eutherian species. Therefore, in this study, we characterized the transcriptome of both the chorioallantois and the endometrium across gestation in the mare. To this end, we collected paired endometrium and chorioallantois from mares at 4, 6, 10 and 11 months of gestation (n=4 /stage), as well as 45 day and postpartum chorioallantois (n=4) and endometrium from diestrus mares (n=3), with all animal procedures following and approved by IACUC (#2014-1341).
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research