Progesterone and 5 α-dihydroprogesterone (DHP) in Cyclic Mares, and in Ovariectomized Mares and Geldings After Progesterone Administration

The significance of the bioactive, 5 α-reduced progesterone metabolite, 5α-dihydroprogesterone (DHP; placentally-derived in late gestation) in equine pregnancy is well supported by in vivo and in vitro data (Scholtz et al., Proc Natl Acad Sci, 2014; 111:3365-3370). Whether DHP circulates at relevant concentrations in cyclic mares rem ains unknown and, if so, does synthesis involve the non-pregnant uterus? Daily blood samples were drawn from cyclic mares (n=5). In additional experiments, ovariectomized mares (OVX, n=3) and geldings (n=3) were given progesterone (300mg) by intramuscular injection.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research