Alteration of the Mare ’s Immune System by the Synthetic Progestin, Altrenogest

The equine industry utilizes synthetic progestins for a variety of applications, including therapeutic, contraceptive, and behavioral modifications. The most commonly administered progestin is altrenogest, although this drug has been associated with an increased risk of uterine inflammation during early diestrus. In addition, a study found that foals born to mares receiving altrenogest during late gestation had a significantly lower lymphocyte/neutrophil ratio compared to controls, indicating a potential effect on the immune system.
Source: Journal of Equine Veterinary Science - Category: Veterinary Research Authors: Source Type: research