SWI/SNF protein expression status in fumarate hydratase –deficient renal cell carcinoma: immunohistochemical analysis of 32 tumors from 28 patients

Fumarate hydratase –deficient renal cell carcinoma (FH-RCC) is a rare, aggressive RCC type, originally described in the setting of hereditary leiomyomatosis and RCC syndrome, which is defined by germline FH gene inactivation. Inactivation of components of the switch/sucrose nonfermentable (SWI/SNF) chromatin remodel ing complex is involved in renal medullary carcinoma (SMARCB1/INI1 loss), clear cell RCC (PBRM1 loss), and subsets of dedifferentiated RCC of clear cell, chromophobe, and papillary types (loss of different SWI/SNF components).

Source: Human Pathology - April 21, 2018 Category: Pathology Authors: Abbas Agaimy, Mahul B. Amin, Anthony J. Gill, Bernt Popp, Andr é Reis, Daniel M. Berney, Cristina Magi-Galluzzi, Mathilde Sibony, Steven C. Smith, Saul Suster, Kiril Trpkov, Ondřej Hes, Arndt Hartmann Tags: Original contribution Source Type: research