Increased toxicity of amylin (Islet Amyloid Polypeptide) in beta cells induced by photochemical internalization

Amylin, synonymously IAPP, and oligomers formed from amylin are implicated in the demise of beta cells in type 2 diabetes [1]. It is unresolved whether oligomers are toxic inside beta cells [2]. Toxicity of intracellularly located oligomers is difficult to test due to their enclosure by endosomes, something that obviates toxicity. This situation is similar to the reduction of desired effects of cytotoxic agents on neoplastic cells due to endosomal wrapping [3]. Use of photochemical internalization (PCI) technique, which enables bursting of endosomes, may give clues for impact of intracellular toxicity as documented in vitro and in vivo [4].

Source: Photodiagnosis and Photodynamic Therapy - June 21, 2018 Category: Laser Surgery Authors: Rinku Singh, Hals Ingrid, H øgset Anders, Grill Valdemar, A. Gederaas Odrun Source Type: research