Alternate pathway to ascorbate induced inhibition of Mycobacterium tuberculosis

In this study, we observed that ascorbate can inhibit M. tuberculosis isocitrate lyase (MtbICL) with an IC50 of 2.15  mΜ. MtbICL is an essential enzyme for the survival of M. tuberculosis under dormancy. We studied the effect of ascorbate on the growth of M.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Tags: Drug Discovery and Resistance Source Type: research