Alternate pathway to ascorbate induced inhibition of Mycobacterium tuberculosis
In this study, we observed that ascorbate can inhibit M. tuberculosis isocitrate lyase (MtbICL) with an IC50 of 2.15 mΜ. MtbICL is an essential enzyme for the survival of M. tuberculosis under dormancy. We studied the effect of ascorbate on the growth of M.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Harish Shukla, Shaheb Raj Khan, Rohit Shukla, Manju Yasoda Krishnan, Md. Sohail Akhtar, Timir Tripathi Tags: Drug Discovery and Resistance Source Type: research