Deletion of PPAR γ in lung macrophages provides an immunoprotective response against M. tuberculosis infection in mice

Peroxisome proliferator-activated receptor gamma (PPAR γ) is a nuclear transcription factor belonging to the superfamily of ligand-activated nuclear receptors. It is activated by diverse endogenous lipid metabolites as well as by exogenous ligands such as the thiazolidinediones. Its activity regulates cellular metabolism, proliferation, differentiation , and inflammation, the latter in part through trans-repression of pro-inflammatory cytokines. PPARγ is highly expressed in alternatively activated alveolar macrophages (AMs), a primary host cell for airborne Mycobacterium tuberculosis (M.

Source: Tuberculosis - June 20, 2018 Category: Respiratory Medicine Authors: Evelyn Guirado, Murugesan VS. Rajaram, Ajay Chawla, Joanna Daigle, Krista MD. La Perle, Eusondia Arnett, Joanne Turner, Larry S. Schlesinger Tags: Immunological Aspects Source Type: research