A trithiol bifunctional chelate for 72,77As: A matched pair theranostic complex with high in vivo stability

Trithiol chelates are suitable for labeling radioarsenic (72As: 2.49  MeV β+, 26 h; 77As: 0.683 MeV β−, 38.8 h) to form potential theranostic radiopharmaceuticals for PET imaging and therapy. To investigate the in vivo stability of trithiol chelates complexed with no carrier added (nca) radioarsenic, a bifunctional trithiol chelate was developed, and conj ugated to bombesin(7–14)NH2 as a model peptide.

Source: Nuclear Medicine and Biology - March 10, 2018 Category: Nuclear Medicine Authors: Yutian Feng, Anthony J. DeGraffenreid, Michael D. Phipps, Tammy L. Rold, Nkemakonam C. Okoye, Fabio A. Gallazzi, Charles L. Barnes, Cathy S. Cutler, Alan R. Ketring, Timothy J. Hoffman, Silvia S. Jurisson Source Type: research