Progression of Hypertrophy and Myocardial Fibrosis in Aortic Stenosis: A Multicenter Cardiac Magnetic Resonance Study [Valvular Heart Disease]

Conclusions:
In patients with aortic stenosis, cellular hypertrophy and diffuse fibrosis progress in a rapid and balanced manner but are reversible after AVR. Once established, midwall LGE also accumulates rapidly but is irreversible post valve replacement. Given its adverse long-term prognosis, prompt AVR when midwall LGE is first identified may improve clinical outcomes.

Clinical Trial Registration:
URL: https://www.clinicaltrials.gov. Unique identifiers: NCT01755936 and NCT01679431.

Source: Circulation: Cardiovascular Imaging - June 18, 2018 Category: Radiology Authors: Everett, R. J., Tastet, L., Clavel, M.-A., Chin, C. W. L., Capoulade, R., Vassiliou, V. S., Kwiecinski, J., Gomez, M., van Beek, E. J. R., White, A. C., Prasad, S. K., Larose, E., Tuck, C., Semple, S., Newby, D. E., Pibarot, P., Dweck, M. R. Tags: Fibrosis, Valvular Heart Disease, Magnetic Resonance Imaging (MRI) Source Type: research