Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats

About 50% of very low birth-weight infants with a gestational age are affected by bronchopulmonary dysplasia (BPD) [1], also known as chronic lung disease of pre- maturity, which is the most common chronic lung disease of infancy in industrialized countries [2]. The survival rate of premature infants has been significantly enhanced because of the advances in mechanical ventilation and oxygen supplementation [3], followed by a high morbidity of BPD [4]. BPD results in serial re-hospitalisations during the first year of life, long-term pulmonary damages and delay of neurodevelopment [2].
Source: Nutrition - Category: Nutrition Authors: Source Type: research