Diffusion of antibiotics in intervertebral disc
Delivering charged antibiotics to the intervertebral disc is challenging because of the avascular, negatively charged extracellular matrix (ECM) of the tissue. The purpose of this study was to measure the apparent diffusion coefficient of two clinically relevant, charged antibiotics, vancomycin (positively charged) and oxacillin (negatively charged) in IVD. A one-dimensional steady state diffusion experiment was employed to measure the apparent diffusion coefficient of the two antibiotics in bovine coccygeal annulus fibrosus (AF) tissue.
Source: Journal of Biomechanics - Category: Biomedical Science Authors: Alicia R. Jackson, Adam Eismont, Lu Yu, Na Li, Weiyong Gu, Frank Eismont, Mark D. Brown Tags: Short communication Source Type: research
More News: Biomedical Science | Study