Factors influencing recruitment to a uk randomised controlled treatment trial; the role of patient-preference
Recruitment to target is a major challenge for randomised controlled treatment trials (RCTs) in psychiatry. Strong patient preference may hamper recruitment of protocol-eligible participants, thereby compromising statistical power and limiting the external validity and generalisability of study findings to target populations. The Optimal Treatment in OCD (OTO) is a UK non-placebo feasibility trial of CBT and sertraline (two standard treatments) and their combination, randomly allocated, designed to ascertain the optimal community-based treatment for OCD.
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Ricky A Sachdev, Srinivas Gopi, Karen Irvine, Yana Varlakova, Thanusha Balakumar, Jasmine Hanson, Sukhwinder Kaur, Virender Marwah, Jemma Reid, Sonia Shahper, Sally Otto, Solange Wyatt, Davis Mpavenda, David M Wellsted, Tim M Gale, Naomi A Fineberg Source Type: research