A hypothetical method for controlling highly glycolytic cancers and metastases

Most proliferating cancer cells and cancer-associated tumor stroma have an upregulated glucose energy demand in relation to normal cells. Cancer cells are further less metabolically flexible than normal cells. They can therefore not survive metabolic stress as well as normal cells can. Metabolic deprivation thus provides a potential therapeutic window.Unfortunately, current glucose blockers have toxicity problems. An alternative way to reduce a cancer patient ’s blood glucose (BG), for a short-term period to very low levels, without the concomitant toxicity, is hypothesized in this paper.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research