Smoking impact on HPV driven head and neck cancer ’s oncological outcomes?

HPV-driven oropharyngeal cancer (OPC) patients are characterized by a better prognosis than their HPV-negative counterparts with a 5  year mortality rate cut in half [1,2]. However this significant survival advantage is not homogeneous and several studies have suggested that among HPV-positive patients those with a smoking history had worse oncological outcomes and a significantly increased risk of death [2–8]. For instance, Huang et al. reported that the 5-year median overall survival was 89% in patients with stage I-II disease (95% CI 85–93%) and a tobacco consumption ≤20 pack year (PY) versus 64% (95% CI 56–73%) in those who smoked more [8].

Source: Oral Oncology - May 25, 2018 Category: Cancer & Oncology Authors: Haitham Mirghani, Charlotte Leroy, Younes Chekourry, Odile Casiraghi, Anne Aup érin, Yungan Tao, France Nguyen, Even Caroline, Ingrid Breuskin, Antoine Moya Plana, Dana Hartl, François Janot, Stéphane Temam, Philippe Gorphe, Pierre Blanchard Source Type: research