HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma

The Notch signaling pathway regulates normal cell growth, survival and differentiation, while alterations in Notch signaling are implicated in numerous malignancy types including head and neck squamous cell carcinoma (HNSCC) [1 –4]. Although Notch signaling is aberrant in a significant subset of HNSCCs, the underlying mechanisms and clinical significance of these alterations are not well understood. A role for Notch signaling in HNSCC was first described when the NOTCH1 gene was found to carry mutations in 10–15% of HN SCCs [2,3,5,6].

Source: Oral Oncology - June 1, 2018 Category: Cancer & Oncology Authors: Eleni M. Rettig, Justin A. Bishop, Nishant Agrawal, Christine H. Chung, Rajni Sharma, Fernando Zamuner, Ryan J. Li, Wayne M. Koch, Joseph A. Califano, Theresa Guo, Daria A. Gaykalova, Carole Fakhry Source Type: research