Effects of Methylene Blue-mediated Photodynamic Therapy on a Mouse Model of Squamous Cell Carcinoma and Normal Skin

Photodynamic therapy (PDT) is used for the treatment of various types of cancers, precancerous lesions, and dermatological disorders. PDT uses dyes or pigments, referred to as photosensitizers, that absorb visible light and induce or participate in photochemical reactions. The photosensitizer is injected into the target tissue under visible light irradiation of an appropriate wavelength, which results in cell damage. Photochemical reactions of types I and II may occur separately or simultaneously to generate cytotoxic products, such as singlet oxygen (1O2), a highly reactive molecule [1,2].

Source: Photodiagnosis and Photodynamic Therapy - June 14, 2018 Category: Laser Surgery Authors: Ana Paula da Silva, Camila Lima Neves, Elizangela dos Anjos Silva, Tania Cristina Lima Portela, Renata Stecca Iunes, Bruno Cogliati, Divinomar Severino, Maur ício da Silva Baptista, Maria Lúcia Zaidan Dagli, Francisco Javier Hernandez Blazquez, José Ro Source Type: research