Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers

Conclusions: Our findings indicate that DDX21 expression in breast cancer cells can promote AP-1 activity and rRNA processing, and thus, promote tumorigenesis by two independent mechanisms. DDX21 could serve as a marker for a subset of breast cancer patients with higher proliferation potential and may be used as a therapeutic target for a subset of breast cancer patients.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research