Hodgkin lymphoma of the gastrointestinal tract in patients with inflammatory bowel disease: portrait of a rare clinical entity

According to the WHO classification, ‘other iatrogenic immunodeficiency-associated lymphoproliferative disorders’ (LPD) are lymphoid proliferations or lymphomas arising in patients treated with immunosuppressive drugs for autoimmune diseases or disorders other than the post-transplant setting [1]. LPD that develop in patients with inflammatory bowel disease (IBD) as a background are included in this category. In 2002, Kandiel et al. performed a meta-analysis demonstrating a fourfold increased risk of lymphoma in the subgroup of IBD patients treated with azathioprine and/or 6-mercaptopurine (6-MP), compared to the risk in the general population [2].

Source: Leukemia Research - June 13, 2018 Category: Hematology Authors: Merav Barzilai, Aaron Polliack, Irit Avivi, Yair Herishanu, Ron Ram, Catherine Tang, Chava Perry, Nadav Sarid Source Type: research