Impact of Pituitary-Gonadal Axis Hormones on Pulmonary Arterial Hypertension in MenNovelty and Significance [Pulmonary Hypertension]

The association of sex hormone (estradiol, testosterone, and progesterone) with cardiopulmonary disease has already attracted great attention, especially in pulmonary arterial hypertension (PAH). However, the impact of sex hormones and their pituitary stimulators (follicle-stimulating hormone and luteinizing hormone) on PAH in men remains unclear. We conducted a prospective cohort study recruiting 95 patients with idiopathic PAH from 2008 to 2014 and following up for a median of 65 months for death. Compared with control, abnormal plasma levels of sex hormones were more common in patients with PAH. Higher estradiol and estradiol/testosterone levels were associated with risk of PAH diagnosis (odds ratio per ln estradiol, 3.55; P
Source: Hypertension - Category: Cardiology Authors: Tags: Risk Factors, Pulmonary Hypertension, Prognosis Original Articles Source Type: research