The potential protective effects of cannabinoid receptor agonist WIN55,212-2 on cognitive dysfunction is associated with the suppression of autophagy and inflammation in an experimental model of vascular dementia

Vascular dementia (VaD), a common dementing illness in aged people, is characterized by a progressive memory and cognitive decline (Smith,  2017). Increasing evidence suggests that vascular risk factors, including cerebral hypoperfusion (i.e., atherosclerosis, carotid artery stenosis), cerebral angiopathy (i.e., cerebral amyloid angiopathy, cerebral small vessel disease), and cardiovascular disease (i.e., hypertension, diabetes, and h yperlipidaemia), contribute to human VaD (Iadecola, 2013). As a main vascular risk factor of VaD, chronic cerebral hypoperfusion (CCH) usually induces neurodegeneration, neuroinflammation, and white matter injury in patients and animal models (Kitamura et al., 2017).
Source: Psychiatry Research - Category: Psychiatry Authors: Source Type: research