Response of NPY immunoreactivity in the tadpole brain exposed to energy rich and energy depleted states

The central control of feeding in animals depends upon the alternating actions of orexigenic and anorectic peptides. Studies at understanding the food intake mechanisms have emphasised the role of Neuropeptide Y as a potent orexigenic peptide in the brain. The aim of this study is to investigate the response of NPY system to positive and negative energy states and elucidate a holistic response of NPY expression throughout the brain of a tadpole model. The pre-metamorphic tadpoles of Euphlyctis cyanophlyctis were subjected to fasting, or intra-cranially injected with glucose or 2-deoxy-d-Glucose (2DG)-a metabolic antagonist of glucose and the response of the NPY system in the entire brain was studied using immunohistochemistry.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research