Evaluation of IP-10 in Quantiferon-Plus as biomarker for the diagnosis of latent tuberculosis infection

The QuantiFERON-TB Gold Plus (QFT-Plus) is a new test for latent tuberculosis infection (LTBI) diagnosis, in which has been added a new tube containing shorter peptides stimulating CD8 T-cells and CD4-stimulating-peptides. Measurement of alternative biomarkers to Interferon- γ (IFN-γ) in QFT-Plus may improve its sensitivity. Interferon-γ inducible protein 10 (IP-10), has been proposed as a tuberculosis (TB) biomarker. We aimed to evaluate the IP-10 accuracy in QFT-Plus for LTBI diagnosis.QFT-Plus was performed in 36 active TB, 31 LTBI and 16 healthy donors (HD).

Source: Tuberculosis - June 12, 2018 Category: Respiratory Medicine Authors: Linda Petrone, Valentina Vanini, Teresa Chiacchio, Elisa Petruccioli, Gilda Cuzzi, Vincenzo Schinin à, Fabrizio Palmieri, Giuseppe Ippolito, Delia Goletti Source Type: research