Improving the accuracy of pancreatic cancer clinical staging by exploitation of nanoparticle-blood interactions: A pilot study

Pancreatic ductal adenocarcinoma (PDAC) early diagnosis is   crucial  and new, cheap and user-friendly techniques for biomarker identification  are  needed. “Protein corona” (PC) is emerging a new bio-interface potentially useful in tumor early diagnosis. In a previous investigation, we showed that relevant differences between the  protein pat terns of  PCs formed on lipid NPs after exposure to PDAC and non-cancer plasma  samples exist. To extend that research, We performed this pilot study to investigate the effect of PDAC tumor size and distant metastases on PC composition.
Source: Pancreatology - Category: Gastroenterology Authors: Source Type: research