Toxic epidermal necrolysis data from the CELESTE multinational registry. Part II: Specific systemic and local risk factors for the development of infectious complications

Toxic epidermal necrolysis (TEN) is a rare systemic disease, which arises from a type IV hypersensitivity reaction (DTH, delayed type of hypersensitivity) [1]. From the pathophysiological point of view, it is a large apoptosis of keratinocytes in the area of dermo-epidermal junction [2,3]. Presently, several mechanisms are described that lead to the induction of epidermal cell apoptosis in patients with TEN [4].

Source: Burns : Journal of the International Society for Burn Injuries - June 11, 2018 Category: Cosmetic Surgery Authors: B. Lipov ý, J. Holoubek, M. Hanslianová, M. Cvanová, L. Klein, I. Grossová, R. Zajíček, P. Bukovčan, J. Koller, M. Baran, P. Lengyel, L. Eimer, M. Jandová, M. Košťál, P. Brychta, CELESTE Study Group Source Type: research