FOXP3-positive T-cell lymphomas in non-HTLV1 carriers include ALK-negative anaplastic large cell lymphoma: expanding the Spectrum of T-cell lymphomas with regulatory phenotype

We report 6 cases of T-cell lymphomas with Treg phenotype based on diffuse positivity for FOXP3 in tumor cells. The patients showed a median age of 56years with a male predominance. Sites of disease included lymph nodes (4), skin (2), subcutaneous tissue (1) and bone marrow (1). All cases showed monomorphic large cells, some with Hodgkin-like or anaplastic cells. All cases expressed pan T cell markers and lacked cytotoxic markers; one case showed diffuse PD1 staining.

Source: Human Pathology - June 10, 2018 Category: Pathology Authors: Cristiane R. Ferreira, Shuchun Zhao, Malaya K. Sahoo, Benjamin Pinsky, Jenna Weber, Luis A.P.C. Lage, Juliana Pereira, Maria C.N. Zerbini, Yasodha Natkunam Tags: Original Contributions Source Type: research