Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund¿s adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats

Conclusions: These results suggest differential efficacy of sustained pain stimuli to depress brain reward function in rats as assessed with ICSS. Formalin-induced depression of ICSS does not appear to engage brain kappa opioid systems.

http://www.molecularpain.com/content/10/1/62

Source: Molecular Pain - September 23, 2014 Category: Molecular Biology Authors: Michael LeitlDavid PotterKejun ChengKenner RiceWilliam CarlezonS Negus Source Type: research