Neutrophil CD64, TLR2 and TLR4 expression increases but phagocytic potential decreases during tuberculosis

During initial stages of pathogen recognition during tuberculosis infection, neutrophils provide significant immune resistance. This is exhibited by phagocytosis of the pathogen, apoptosis, activation of downstream immune responses, etc. As pathogen recognition by neutrophil cell surface receptor and phagocytosis marks the initial step in any immune response, knowledge on receptor modulations during tuberculosis infection will augment drug designing strategies for the disease. Thus we studied the phagocytosis potential and expression of toll like receptors (TLR1, TLR2 and TLR4) and Fc γ receptors (CD64 and CD32) by human neutrophils following infection with Mycobacterium tuberculosis strains.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Tags: Immunological Aspects Source Type: research