Effect of tadalafil on reduction of necrosis in the ischemic zone in a rat comb burn model

Burns are dynamic wounds in which the extent of injury tends to progress over time due to a combination of ischemia-reperfusion due to decreased perfusion, inflammation and oxidative stress [1 –5]. In his monumental paper in 1953 Jackson described how burns classically affected the skin [6]. The zone directly in contact with the thermal insult underwent immediate and complete necrosis and was termed the zone of necrosis. Immediately surrounding this inner core was a zone of ischemia or stasis in which the microcirculation was diminished, but if improved, was potentially reversible.
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research