The toxic effect of aflatoxin B1 on early porcine embryonic development Running head: The effect of AFB1 on porcine embryos

Aflatoxin B1 (AFB1) is a type of mycotoxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus. AFB1 is considered as the most toxic mycotoxin owing to its toxic effect on health. In the present study, the toxic effect of AFB1 on early porcine embryonic development and its possible mechanism were investigated. Blastocyst formation was impaired with treatment of 1 nM AFB1 compared with control, 0.01, 0.1 group (40.13 ± 2.10%, 28.21 ± 1.62%, 32.34 ± 2.07% vs 19.01 ± 1.06%). Further study showed that the presence of AFB1 induced the generation of reactive oxygen species (ROS).

Source: Theriogenology - June 8, 2018 Category: Genetics & Stem Cells Authors: Kyung-Tae Shin, Jing Guo, Ying-Jie Niu, Xiang-Shun Cui Source Type: research