Association between IL-15 and insulin plasmatic concentrations in patients with pulmonary tuberculosis and type 2 diabetes

IL-15 is part of the immune response in pulmonary tuberculosis (PTB) but amazingly, it may also induce physiological effects similar to those of insulin. We evaluated the IL-15 and insulin plasmatic levels in adults with PTB and with or without type 2 diabetes mellitus (DM2), who received previous antituberculosis therapy for at least 2 months. We analyzed the concentrations of glucose, glycated hemoglobin, insulin, as well as levels of IL-15, IL-2, IFN- γ, and TNF-α in patients with PTB, patients with PTB-DM2, household contacts with DM2 (C-DM2), and healthy household contacts (H-C).

Source: Tuberculosis - June 8, 2018 Category: Respiratory Medicine Authors: Roberto S ánchez-Jiménez, Eduarda Cerón, Demetrio Bernal-Alcántara, Manuel Castillejos-López, Eva Gonzalez-Trujano, Ma Cristina Negrete-García, Noé Alvarado-Vásquez Source Type: research