Pseudo Chediak-Higashi anomaly in blasts from acute lymphoblastic leukemia

We here report a case of acute lymphoblastic B-lineage leukemia (B-ALL) with pseudo Chediak-Higashi (PCH) granules, which represents a rare occurrence in an adult patient. Previously, only few cases, mostly of pediatric age range, have been described in the literature (Table 1). Chediak-Higashi syndrome is a rare autosomal recessive disorder characterized by immunodeficiency, oculocutaneous albinism, neurologic abnormalities and coagulation defects caused by loss of function of the lysosomal trafficking regulator CHS1/LYST gene [1].

Source: Leukemia Research - June 8, 2018 Category: Hematology Authors: M Gavillet, Spertini Olivier, S Blum Tags: Letter to the Editor Source Type: research