Chapter 22 Identifying therapeutic targets and treatments in model systems

Publication date: 2018 Source:Handbook of Clinical Neurology, Volume 153 Author(s): Corinne Lasmézas, Ruth Gabizon In this chapter, we describe current therapeutic targets for prion diseases. We focus on targets that have been validated in vitro and in vivo, leaving out a plethora of theoretic targets that still require validation. We also show how the development of improved model systems for the study of prion infection and neurotoxic mechanisms has enabled target identification. Some therapeutic targets are prion-specific, such as PrPTSE, while others are shared by other neurodegenerative diseases, for example, autophagy, cholesterol and energy metabolism, and neuroinflammation. In vivo models are discussed, and a genetic model of Creutzfeldt–Jakob disease particularly well suited for evaluation of prophylactic intervention is described in more detail.
Source: Handbook of Clinical Neurology - Category: Neurology Source Type: research