Mycobacterium bovis ESAT-6, CFP-10 and EspC antigens show high conservation among field isolates

ESAT-6, CFP-10 and EspC are virulence factors that have been extensively assayed for bovine and human tuberculosis diagnosis due their potent T-cell inducing activities. While polymorphisms of ESAT-6 and CFP-10 were analyzed, with the description of CFP-10 variants in M. tuberculosis, this fact has not been explored in M. bovis field isolates. The coding sequences of esxA (ESAT-6), esxB (CFP-10) and mb3645c (EspC) from 58 M. bovis strains exhibiting genomic variability (spoligotyping) were analyzed.

Source: Tuberculosis - June 7, 2018 Category: Respiratory Medicine Authors: M. Encinas, J. Marfil, S. Garbaccio, S. Barandiaran, P. Huertas, C. Morsella, A. Mac ías, G. Magnano, L. Zapata, F. Bigi, A. Cataldi, F. Paolicchi, M. Zumárraga, M.E. Eirin Source Type: research