Toxic epidermal necrolysis data from the CELESTE multinational registry. Part I: Epidemiology and general microbiological characteristics

Toxic epidermal necrolysis (TEN) is a life-threatening autoimmune disease predominantly manifested in the skin and mucous membranes [1]. It is a toxic allergic reaction to the presence of a foreign antigen, most commonly a medication [2]. The pathophysiological basis of this disease is the induction of massive apoptosis in the area of dermo-epidermal junction by caspase and non-caspase mechanisms [3,4].

Source: Burns : Journal of the International Society for Burn Injuries - June 6, 2018 Category: Cosmetic Surgery Authors: B. Lipov ý, J. Holoubek, M. Hanslianová, M. Cvanová, L. Klein, I. Grossová, R. Zajíček, P. Bukovčan, J. Koller, M. Baran, P. Lengyel, L. Eimer, M. Jandová, M. Košťál, P. Brychta, CELESTE Study Group Source Type: research