A Comparison of Direct and Indirect Methods for the Estimation of Health Utilities from Clinical Outcomes

Conclusions: There are limited data from patients in the most severe HAQ health states. Modeling of EQ-5D from clinical measures is best performed directly using the bespoke mixture model. This substantially outperforms the indirect method in this example. Linear models are inappropriate, suffer from systematic bias, and generate values outside the feasible range.
Source: Medical Decision Making - Category: Health Management Authors: Tags: Original Articles Source Type: research