Comparative genomic analysis of oral versus laryngeal and pharyngeal cancer

Definitive (chemo)radiotherapy (CRT) is a curative treatment option for inoperable, locally advanced oral squamous cell carcinoma (OSCC) [1]. However, it appears that definitive CRT in OSCC does not achieve similarly high locoregional control or disease specific survival rates as in laryngeal and pharyngeal squamous cell carcinoma (L/P-SCC) [2,3]. Current HNSCC treatment guidelines reflect this and L/P-SCC is preferably treated with definitive CRT and OSCC with surgery followed by postoperative radiotherapy with or without chemotherapy (S-PORT).

Source: Oral Oncology - April 13, 2018 Category: Cancer & Oncology Authors: David M. Vossen, Caroline V.M. Verhagen, Marcel Verheij, Lodewyk F.A. Wessels, Conchita Vens, Michiel W.M. van den Brekel Source Type: research