The role of protein methyltransferases as potential novel therapeutic targets in squamous cell carcinoma of the head and neck

Over the past decade, multiple studies have uncovered the significance of protein methylation in cancer development and progression. Protein lysine (PKMTs) and arginine (PRMTs) methyltransferases comprise a group of 62 enzymes that mediate the reversible deposition of methyl groups on lysine and arginine residues, respectively, on either histone or non-histone substrates. Protein demethylases (PDMTs) comprise approximately 30 enzymes and they erase these marks. Studies conducted by the Cancer Genome Atlas (TCGA) consortium have revealed multiple genetic and expression level alterations in these enzymes in multiple cancer types, including squamous cell carcinoma of the head and neck (SCCHN) [1].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Review Source Type: research