Molecular targets of celastrol in cancer: Recent trends and advancements

In the past few decades, the interest in medicinal plants and their bioactive molecules has extensively grown, and many of such agents exhibit diverse effects on suppressing the development and progression of neoplasms, both in vitro as well in vivo animal models (Kashyap et al., 2016d; Kumar et al., 2016; Tuli et al., 2014). It is widely believed that such substances can provide a plausible alternative to synthetic drugs due to their potency, safety, and lower cost (Hansen et al., 2011). One of such potential natural agent is celastrol, a quinine methide triterpenoid.

Source: Critical Reviews in Oncology Hematology - June 5, 2018 Category: Cancer & Oncology Authors: Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Tapan Mukherjee, Anupam Bishayee Source Type: research