Reversal of loss of bone mass in old mice treated with mefloquine

We examined herein the effect of mefloquine, a drug used to treat malaria and systemic lupus erythematosus and shown to ameliorate bone loss in glucocorticoid-treated patients, on bone mass and mechanical properties in young and old mice. Young 3.5-month-old and old 21-month-old female C57BL/6 mice received daily injections of 5  mg/kg/day mefloquine for 14 days.

Source: Bone - June 4, 2018 Category: Orthopaedics Authors: Rafael Pacheco-Costa, Hannah M. Davis, Emily G. Atkinson, Julian E. Dilley, Innocent Byiringiro, Mohammad W. Aref, Matthew R. Allen, Teresita Bellido, Lilian I. Plotkin Tags: Full Length Article Source Type: research