Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF¿B) pathway

Conclusions: This work highlights the importance of GLI1 in the maintenance of characteristics of metastatic breast cancer stem cells. Remarkably, treatment with an inhibitor of the NF?B pathway reproducibly reduces GLI1 expression and protein levels. We further provide direct evidence for the binding of the NF?B subunit p65 to the GLI1 promoter in both EMT and claudin-low cell lines. Our results uncover crosstalk between NF?B and GLI1 signals and suggest that targeting these pathways may be effective against the claudin-low breast cancer subtype.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research