Depletion of CD4+ T-helper cells reduces pancreatic damage in two models of acute pancreatitis.

Objectives Acute pancreatitis is characterized as self-digestion of the pancreas by its own proteases. This process is accompanied by a local and systemic immune response. While cells of the innate immune system migrate into the pancreas, cells of the adaptive immune system like T-cells do not infiltrate the organ, but still undergo activation in the spleen and the surrounding lymph-nodes. The aim of this study was to investigate the role of T-cells during acute pancreatitis.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Juliane Glaubitz, Anika Wilden, Cindy van den Brandt, Frank Ulrich Weiss, Julia Mayerle, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research