LMP7 immunoproteasome knockout mice show delayed inflammatory response during acute pancreatitis: protective or harmful effect?

Objectives Acute pancreatitis is a primarily sterile disease characterized by a severe systemic inflammatory response associated with extensive necrosis and a mortality rate of up to 24%. Since some studies have linked the proteasome with immune response activation, mainly through LMP7 immunoproteasome subunit inhibition, our aim in this work was to investigate its role in pancreatitis.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Laura Let ícia de Freitas Chama, Frank Ulrich Weiß, Elke Krüger, Markus M. Lerch, Matthias Sendler Tags: 3. Experimental Pancreatitis I Source Type: research