Expression of the obestatin/G-protein coupled receptor 39 (GPR39) system in healthy and diseased human pancreas

Objectives Obestatin, a 23-amino acid peptide encoded by the ghrelin gene, and the GPR39 receptor were reported to be involved in the control of mitogenesis of gastric cancer cell lines. Our data strongly suggest the involvement of the obestatin/GPR39 system in the pathogenesis and/or clinical outcome of human gastric adenocarcinomas and highlight the potential usefulness of GPR39 as a prognostic marker in gastric cancer. Although this system has been described in the rat endocrine pancreas, its exact expression and function in human pancreas has not been assessed yet.

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Lara Est évez-Perez, Saul Leal-lopez, Agustin Sanchez-Temprano, Begoña Otero-Alen, Carlos Seoane-Mosteiro, Rosalia Gallego- Gomez, Ihab Abdulkader-Nallib, Tomas Garcia-Caballero, J Enrique Dominguez-Muñoz, Jesus Perez-Camiña, Yolanda Pazos-Randulfe Tags: 4. Genetics in pancreatic diseases Source Type: research