Genetic variability of the ABCC2 gene and overall survival in pancreatic cancer

Objectives Context: The critical role of the ATP binding cassette subfamily C member 2 (ABCC2) protein in the response to various drugs has been documented in several reports. It is more recent knowledge that the ABCC2 gene is differently expressed in gemcitabine sensitive and resistant cells. Moreover, Single Nucleotide Polymorphisms (SNPs) in the gene have been associated with differential outcomes and prognosis in several tumour types. Objective: The aim of this study was to investigate the possible association between SNPs in the ABCC2 gene and overall survival in PDAC patients.

https://www.pancreatology.net/article/S1424-3903(18)30201-1/fulltext?rss=yes

Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Manuel Gentiluomo, Alice Galeotti, Raffaele Pezzilli, Ugo Boggi, Gabriele Capurso, Ewa Ma łecka-Panas, Juozas Kupcinskas, Markus Büchler, Angelo Andriulli, William Greenhalf, John P. Neoptolemos, Andrea Mambrini, Aldo Scarpa, Pavel Soucek, Martin Lovece Tags: 4. Genetics in pancreatic diseases Source Type: research